DNA Modification & Modifying Enzymes

a DNA double helix with a segment being removed and modified

Overview & Resources

DNA is the central information storage system for all organisms, excluding some viruses that only have RNA as their genetic material. It was first discovered in the late 1860s by Swiss chemist Frederich Miescher.

However, decades passed and several notable discoveries were made before DNA’s importance was realized and appreciated. Among these discoveries was the unearthing of its helical structure in 1953 by Watson and Crick, using Rosalind Franklin’s clear x-ray patterns.

That said, genetic modification wouldn’t come about until 1973, when American biochemists Stanley N. Cohen and Herbert W. Boyer invented recombinant-DNA technology and subsequently revolutionized the way the scientific community looks at DNA.

Genetic modification, also referred to as DNA Modification or genetic engineering, is a process that involves base modifications or alte rations in the microbial, mammalian, or human genome to achieve targeted goals.

The technique has several applications, including:

  • Synthesis of specific proteins and hormones
  • Developing targeted therapies for several human diseases
  • Crop improvement

DNA modification has allowed researchers to edit the genomic DNA of organisms by using different biotechnology methods, including recombinant DNA, gene targeting, or genome editing.

Learn more below about DNA modification and the consumables and reagents required for cloning experiments and studies.

DNA Modification Resources

Argonaute Protein: Application & Overview

Argonaute Protein: Application & Overview

Argonaute Protein: Overview Argonaut proteins are an essential component of the RNA-induced silencing complex (RISC), responsible for RNA silencing — also known as RNA interference (RNAi).  The p…
Sulfurylase: Application & Overview

Sulfurylase: Application & Overview

Sulfurylase: Overview Sulfurylase is an enzyme that catalyzes the chemical reaction forming pyrophosphate and adenylyl sulfate as products from ATP and sulfate substrates. The enzyme is also known as …
DNA Glycosylase: Application & Overview

DNA Glycosylase: Application & Overview

DNA Glycosylase: Overview In the cellular environment, DNA is under a constant threat of getting involved in a chemical reaction. It can be either due to alkylation, oxidation, or deamination. These r…
DNA Labeling: Overview & Applications

DNA Labeling: Overview & Applications

DNA Labeling: Overview Nucleic acid labeling is one of the essential procedures in molecular biology labs to detect and purify nucleic acids (DNA and RNA).  Various labeling agents are available …
Topoisomerase: Overview & Applications

Topoisomerase: Overview & Applications

Topoisomerase: Overview Topoisomerase (DNA topoisomerases) is an enzyme that catalyzes the changes in the intertwined state of two DNA strands. It helps in vivo and in vitro DNA replication, transcrip…

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