How Raman Microscopy Works & How We Save You Time & Money
Excedr can source all equipment types and can accommodate any model preferences your lab might have. Request a quote today and see how a lease can discount your Raman microscope price.
All equipment brands/models are available
Here are the advantages of Excedr’s Raman microscope leasing program:
- We enable you to make payments over time and remove the burdensome upfront cost of instrument purchases
- Payments may be 100% tax deductible*, which yields you significant cash-savings
- Purchasing equipment outright is often significantly more expensive than leasing through us
- Minimal instrument downtime because we cover repairs and service visits
- We handle and streamline the admin work associated with instrument procurement and maintenance
- The money saved with our leasing program, clients are more capable to reinvest in their core business and operations (staffing, inventory, marketing/sales, etc.)
*Please consult your tax advisor to determine the full tax implications of leasing equipment.
In Raman spectroscopy, properties of a material can be determined by observing how they interact with inelastic scattering of light.
Inelastic scattering refers to when light bounces off an object, it either loses or gains energy. This is achieved by first using a laser to aim light at the sample. The laser is tuned to use light of a specific wavelength. When the light hits the object and scatters, various attributes of the material can be determined by analyzing the scattered light. Its ability to characterize materials makes Raman spectroscopy an important tool in chemistry, materials science, and nanotechnologies.
Initially, Raman microscopy was used to measure Raman spectrums of a sample at specific points on the object however, it now is also used for chemical imaging of samples. Typical Raman microscopes are optical microscopes augmented with the following components:
- Excitation laser
- Laser rejection filter(s)
- Raman spectrometer or monochromator
- Optical Sensor (such as a charged-couple device or a photomultiplier tube)
By taking Raman spectrums at all points on an object and filtering for specific spectral bands an image can be reconstructed from the spectral information. It is this ability to both analyze and produce an image of an object from its Raman spectrum that distinguishes Raman microscopy from Raman spectroscopy. The combination of a spectrometer with a microscope is also why this is called Raman microspectrophotometry.
Raman Microscope Variations, Applications, & Cost
Confocal Raman Microscopy
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Conventional optical microscopes are powerful tools, but they are not able to achieve depth selectivity or spatial filtering. That is to say, they are not able to easily filter out-of-focus areas of the sample. Confocal microscopes are able to achieve volume-specific spatial filtering of a sample on all its axis. When these spatial filters are added to a Raman microscope it is then called a confocal Raman microscope or a true confocal Raman microscope. In confocal Raman microscopy, the resolution is so fine that individual particles as small as 1 micron or less are able to be analyzed. Other factors that will affect these microscope’s resolution are the specific wavelength of the laser and the type of objective that is used.
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Generating images of chemicals pose interesting problems due to the size of the sample that is being imaged and what scientists wish to display. Raman imaging is a technique that uses Raman spectroscopy to develop chemical images by producing false colors representing the chemical makeup of the material. After a full spectrum is taken at each and every pixel of the sample image, specific colors are used to represent the material’s composition, phase, crystallinity, and strain at that pixel. Other imaging techniques that are used include direct imaging, hyperspectral imaging, and correlative imaging. Correlative Raman imaging refers to a group of techniques that combine Raman with other imaging methods. Popular correlative techniques include Raman-SEM, Raman-AFM, and Raman-SNOM.
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The level of chemical analysis and imaging that Raman microscope offers make it a valuable tool in chemistry and chemical identification. When used in biological settings, Raman microspectroscopy is an effective examination tool due to its non-invasive and non-destructive qualities. Additionally, Raman microscopy is not affected by water, meaning that samples can be observed while wet. This makes protein, polysaccharide, and nucleic acid analysis easy due to the minimal sample preparation needed. This type of microscopy also finds use outside of the sciences, being used to detect art forgeries, historical document analysis, and explosives detection.
Media streaming services and clinical science rarely intersect, however, that is exactly what a group of researchers have done in Paris. This group has taken a Netflix algorithm from their preference prediction competition in 2009 and repurposed it for Raman spectroscopy imaging. A diverse group of researchers led by Hilton de Aguiar, they used the algorithm to increase the speed of the imaging process by reducing the amount of spectral data needed. This technique is referred to as compressive Raman imaging. In testing, time can be a crucial factor when ensuring that the test results are valid. If, for example, you are testing a biological sample and the test takes too long, that sample might have degraded, compromising the test result. Science has long drawn inspiration from other areas to come up with unique solutions to problems. The Netflix algorithm may not have won its intended prize, but it will continue to contribute to the scientific community in ways its creators never would have thought possible.
Raman microscopes can provide any lab with a powerful imaging and analysis tool, however, buying one outright can prove to be financially difficult. We’re here to help you with all of your Raman light scattering needs, be it leasing a Raman spectrometer or microscope. Call us at (510) 982-6552 or fill out our contact form online and we can discuss your specific needs in further detail
We Offer Raman Imaging Microscope Leases to Fit Every Need
This off-balance sheet financing structure provides three options at the end of the term. The lessee has the option to return the equipment to the lessor, renew at a discounted rate, or purchase the instrument for the fair market value. Monthly payments are also 100% tax deductible which yields additional monetary savings.
If you recently bought equipment, Excedr can offer you cash for your device and convert your purchase into a long-term rental. This is called a sale leaseback. If you’ve paid for equipment within the last ninety days, we can help you recoup your investment and allow you to make low monthly payments. This also frees up money in your budget rather than tying it down to a fixed asset.
Confocal Raman Microscope Manufacturers & Models on the Market
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DXR2xi, DXR 2 microscope
TCS SP8 CARS
LabRAM HR Evolution, XploRA PLUS, XploRA INV, XploRA ONE
SENTERRA II, SENTERRA II
NRS Series, NRS-4500 Series, NRS-5000 Series, NRS-7000 Series
inVia, inVia Qontor
alpha300 R, access, apyron, alpha300 RI
NT-MDT Spectrum Instruments NTEGRA SPECTRA II