How High-Content Screening Works & How We Save You Time & Money
Excedr’s leasing program can source all instrument types and accommodate any brand preferences you might have. Request an HCS/HCA system lease estimate today and see how leasing can discount your high-content screening instrument’s price.
All equipment brands/models are available
The Advantages of Excedr’s High Content Screening and Analysis Leasing Program:
- Eliminates the upfront cost of purchasing equipment by spreading its cost over time
- Minimizes equipment downtime with included complete repair coverage and preventive maintenance
- Takes advantage of potentially 100% tax deductible* payments, providing you significant cash-savings
- Expedites the administrative work needed for instrument procurement and logistics
- Conserves working capital, enabling you to reinvest in your core business and operations (staffing, inventory, marketing/sales, etc.)
- Accommodates all manufacturer and model preferences
*Please consult your tax advisor to determine the full tax implications of leasing equipment.
High-content screening and analysis (HCS/HCA) are powerful methods used to image and evaluate cells to gain an understanding of phenotypic change at the cellular level.
HCS and HCA systems, which involve automated microscopy and image analysis, were first introduced over twenty years ago. Although the equipment has since evolved, the screening process typically remains universal amongst the scientific community.
Traditional screening and imaging methods limit quantitative results to clusters of thousands of cells. HCS allows a combination of morphological and functional information to be recorded for individual cells. HCS uses automation, fluorescence imaging and detection, and specialized algorithms to provide visualization and quantification for large-scale applications.
These visualizations make it useful in a variety of fields that require live cell imaging, such as drug discovery, cell behavior/mechanisms, and in vitro toxicology studies. HCS systems are also ideal for studying 3D cell culture models.
Like high-throughput screening (HTS), high-content imaging enables a more efficient workflow by automating the imaging process and removing possible investigator bias by providing highly quantitative rather than subjective results.
However, the two techniques have their differences. While HTS binds its targets in larger dimensions, HCS focuses on cell-based target responses, including the change in phenotype of the whole cell. In other words, HCS sacrifices some throughput capabilities for more comprehensive data.
Since its introduction, high-content screening systems have continually evolved. This evolution includes developments to the automated microscope hardware—cameras and confocal optics, for instance—as well as substantial software enhancements, improving image acquisition, analysis, evaluation, and data storage.
HCS improvements have supported the growing high-content screening requirements for higher-throughput, phenotypic screening and assays involving complex disease models, such as live cells, primary cells, stem cells and 3D spheroids.
Methods, Applications & Imaging System Instrumentation
HCS is a multi-step methodology that assists with the image capture and analysis of various biological processes. This imaging technique is highly favored and frequently used in drug screening for its precision.
Although it remains similar in methodology, there are a number of methods and applications to distinguish between. We cover some of those below.
Primary Compound Screening
A Brief History of HSC
High-Content Imaging System Leases to Fit Every Need
If you’re research requires cellular imaging and data analysis via high-content screening, Excedr can help you acquire the HSC/HCA system best suited for your laboratory. Our leasing program spreads out the high costs of specialized life sciences technology through affordable and flexible payment options. Whether you’re interested in a system capable of fluorescence or confocal microscopy, we can help.
Don’t let your research suffer because of exorbitant technology costs. Reach out today to learn more about our program’s benefits and receive an HSC system lease estimate.
This off-balance sheet financing structure provides three options at the end of the term. The lessee has the option to return the equipment to the lessor, renew at a discounted rate, or purchase the instrument for the fair market value. Monthly payments are also 100% tax deductible which yields additional monetary savings.
If you recently bought equipment, Excedr can offer you cash for your device and convert your purchase into a long-term rental. This is called a sale leaseback. If you’ve paid for equipment within the last ninety days, we can help you recoup your investment and allow you to make low monthly payments. This also frees up money in your budget rather than tying it down to a fixed asset.
High-Content Screening Imaging System Manufacturers & Models on the Market
CellInsight CX5, CellInsight CX7, CellInsight CX7 LZR
Operetta CLS High-Content Analysis System, Opera Phenix Plus High-Content Screening System
IN Cell 2500HS, IN Cell 6500HS