Confocal Microscope:

Confocal Microscope

How Confocal Microscopy Works & How We Save You Time & Money

Excedr can source all equipment types and can accommodate any model preferences your lab might have. Request a quote today and see how a lease can discount your confocal microscope’s price.

All equipment brands/models are available

The Advantages of Excedr’s Confocal Microscope Leasing Program:

  • Eliminates the upfront cost of purchasing equipment by spreading its cost over time
  • Minimizes equipment downtime with included complete repair coverage and preventive maintenance
  • Takes advantage of potentially 100% tax deductible* payments, providing you significant cash-savings
  • Expedites the administrative work needed for instrument procurement and logistics
  • Conserves working capital,  enabling you to reinvest in your core business and operations (staffing, inventory, marketing/sales, etc.)
  • Accommodates all manufacturer and model preferences

*Please consult your tax advisor to determine the full tax implications of leasing equipment.

Microscopy is a field of study that focuses on looking at objects that are too small to be seen unassisted by humans, with a microscope.

The main branches of microscopy are optical, scanning probe, and electron. Specifically, optical microscopes utilize light and lenses to magnify objects. Light is directed either to or through the object and the image is transferred either directly to the eye, imaged onto a photographic plate, or digitally analyzed. The most simple type of optical microscopes use one lens, but more complex microscopes use multiple lenses. Similarly, the most common type of light used in optical microscopes is visible light, however, different spectrums of light can also be used.  

Confocal microscopy is an optical microscopy technique that uses lasers as the excitation source and pinhole spatial filters to solve the issues with fluorescence microscopy while increasing the resolution and contrast of the image. By focusing the laser on specific parts of the material, only those specific parts will fluoresce. This excited fluorescence then is picked up by a detector. In front of the detector is the pinhole filter that eliminates the out-of-focus signal. This out-of-focus elimination is where confocal microscopes get their name. Confocal microscopes, which are a type of fluorescence microscope, have a shallow depth of field and collect optical sections from thick specimens. They are used extensively in biology, inspection of semiconductors, and material science.

Confocal Microscopy Techniques, Variations, & Costs

Laser Scanning (CLSM)
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Imaging of a sample’s surface provides a lot of information about that object but does not provide a detailed picture of the entire object. Confocal laser scanning microscopes (CLSM) are able to provide 3D reconstructions of a sample. CLSM adds optical sectioning to standard or wide-field confocal microscopy by allowing for depth selectivity. This is done by passing the laser beam through a light source aperture that allows for depth selectivity. Multiple depths of the object can then be imaged and each depth’s images can be stitched together to achieve a true 3D rendering of the specimen. This imaging technique is also known as optical sectioning.

 

Spinning Disc (SDCLM)
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Due to the multiple layers that are needed to be imaged in CLSM, it is required that the sample remains still, which is relatively time-consuming. Spinning disk laser confocal laser microscopy (SDCLM) is able to mitigate these shortcomings by using multiple pinholes to project multiple parallel excitation light beams. These pinholes are arranged on a rotating Nipkow disk that is located within the microscope plane. Due to the spinning of the disk and the multiple pinholes used, images can be captured at a rate of thousands per second. One disadvantage to this, however, is that due to the holes being larger, the images obtained cannot block out as much background fluorescent light and the result is not as detailed.

 

Programmable Array Microscope (PAM)
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PAM utilizes a similar methodology to SDCLM but is able to have programmable pinholes. It uses a digital micromirror device that is used as a spatial light modulator. This allows that user to tune their microscope light source to match the specific experimental parameters that they are looking at. The microscope can be changed quickly if the experimental conditions require it. The major advantages that PAM has over other confocal microscopy techniques are that it is controlled by software, has no moving parts, and offers complete flexibility in its lighting and detection methods.

 

Serotonin & Decision Making
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Serotonin, one of the better-known neurochemicals, contributes to wellbeing and happiness, however, it may also be vital to understanding how our brains function in more extreme conditions. Recent researchers found that serotonin levels may vary depending on the specific emergency situation that an animal is in. For example, if a mouse is in an exposed field and a hawk is diving down to eat it, the fight-or-flight response kicks in and tells the mouse to run. If however, that same mouse sees the hawk first and the hawk is unaware of the mouse, the more appropriate response is to freeze. Researchers have found that serotonin neurons trigger escape mechanisms in events of high danger. In lower-danger environments, these same neurons trigger a pausing reaction. If true, this discovery could completely change how we view our brains during these emergency situations.

Observing these types of reactions is not easy and requires highly accurate and powerful microscopes. Confocal laser scanning microscopes aid researchers in imaging and understanding how these neurons are triggered and work.

 

Whatever your microscopy needs, be they financing a confocal, multiphoton, or X-Ray Microscope, Excedr has you covered. Call us at (510) 982-6552 or fill out our contact form and we can talk about what specific equipment you would like to lease.

We Offer Real-Time Confocal Laser Scanning Microscope Leases to Fit Every Need

Operating Lease

This off-balance sheet financing structure provides three options at the end of the term. The lessee has the option to return the equipment to the lessor, renew at a discounted rate, or purchase the instrument for the fair market value. Monthly payments are also 100% tax deductible which yields additional monetary savings.

Sale-Leaseback

If you recently bought equipment, Excedr can offer you cash for your device and convert your purchase into a long-term rental. This is called a sale leaseback. If you’ve paid for equipment within the last ninety days, we can help you recoup your investment and allow you to make low monthly payments. This also frees up money in your budget rather than tying it down to a fixed asset.


Spinning Disc Confocal Microscope Manufacturers & Models on the Market
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Zeiss:
Smartproof 5, LSM 9 Family, LSM 900, LSM 980, LSM 900 with Airyscan 2, LSM 980 with Airyscan 2

Super-resolution:
Elyra 7

Olympus:
FV3000, IXplore Spin

Super-Resolution:
IXplore SpinSR

Nikon:
A1 HD25, A1R HD25, C2+, CSU series, CSU-X1, CSU-W1, CSU-W1 SoRa, 

Super-Resolution:
N-SIM S, N-SIM E, N-STORM, 

Leica: 
SP8 DIVE, TCS SP8 DLS, TCS SPE, DCM8, STELLARIS 5, STELLARIS 8, STELLARIS 8 FALCON, TCS SP8 STED, TCS SP8 CARS

Bruker: 
Opterra II

Keyence:
VK-X Series, VK-X1000

Andor:
Dragonfly Models, Dragonfly 200, Dragon 500

Molecular Devices:
ImageXpress Confocal

and more!

 


Operating Capital Benefits

Operating Capital Benefits

Excedr's operating lease structure allows you to keep your business credit line open for expansions, staffing, and other operational expenses. Additionally, it strengthens the cash flow of your business and keeps cash reserves free for business development opportunities.

Effects on Credit

Effects on Credit

Leasing / renting provides you with non-dilutive financing and does not hinder your future borrowing ability. You're able to acquire the equipment you need without the baggage associated with traditional financing.

Used Equipment

Used Equipment

Unlike traditional financing and leasing companies, the Excedr program can accommodate refurbished/reconditioned equipment in addition to demo units. If you are looking for additional cost-savings, we recommend considering this option.

Speed of Approval

Speed of Approval

Excedr's program allows you to respond quickly as your need for equipment and technology arises. You can be approved with minimal documentation and have the equipment you need in operation and generating revenue for your business quickly.