How Homogenization Works & How We Save You Time & Money

Excedr General Lab Equipment Lab Homogenizer

Excedr’s leasing program can source all instrument types and accommodate any brand preferences you might have. Request an estimate today and see how leasing can discount your rotor-stator homogenizer price.

All equipment brands/models are available

The Advantages of Excedr’s Lab Homogenizer Leasing Program:

  • Eliminates the upfront cost of purchasing equipment by spreading its cost over time
  • Minimizes equipment downtime with included complete repair coverage and preventive maintenance
  • Takes advantage of potentially 100% tax deductible* payments, providing you significant cash-savings
  • Expedites the administrative work needed for instrument procurement and logistics
  • Conserves working capital,  enabling you to reinvest in your core business and operations (staffing, inventory, marketing/sales, etc.)
  • Accommodates all manufacturer and model preferences

*Please consult your tax advisor to determine the full tax implications of leasing equipment.

a microplate well leaning against a graduated cylinder on top of glassware storage

Homogenization is a common and necessary procedure in a range of industries and laboratories, as it allows manufacturers and scientists to more easily combine samples. 

Homogenization in the lab is the process by which the components of a substance are broken up into tiny particles equal in size and structure, before being thoroughly mixed back together, creating a homogenous mixture.

This is typically done to substances that are mutually insoluble and immiscible, making them equal in size and, hence, miscible. It differs from emulsification in that emulsifying substances only requires that they are mixed into one another. However, when performing homogenization, emulsification is usually performed first.

In some cases, homogenization is also referred to as micronization or cell fractionation. Although liquids are the most common, scientists also homogenize tissue, food, plant, and soil samples. For example, specific devices, called tissue homogenizers, are made for tasks involving the breaking down of tissue structure to form an emulsion of tissue solids, proteins, and fluid.

Molecular biology, cell biology, and biochemistry laboratories utilize homogenization for research and production, while the biotechnology and pharmaceutical industries implement cell disruption and cell lysis, the process of breaking down a cell’s membrane through viral, enzymic, or osmotic mechanisms, in a variety of ways. While similar to homogenization, these two methods are used in situations where the nucleus should be kept intact.

In molecular biology, PCR is just one application that benefits from homogenization, where sample preparation is vital to achieving accurate results.

Homogenization is a vital part of today’s scientific world, and laboratory homogenizers are best suited for the job. These machines are an important part of any modern laboratory, and aid in everything from simple mixing tasks to the development of cost effective, life-saving medicines and alternative biofuels. 

Laboratory homogenizers come in a variety of styles that operate using different methods of force. These methods offer a myriad of applications, including DNA/RNA extraction, particle size reduction, and the preparation of suspensions, emulsions, and dispersions. 

The mortar and pestle is perhaps the original homogenization method used, having been invented thousands of years ago.

Lab Mixer & Homogenizer Methods, Types & Prices

a hand face up balancing a screw on its index finger

It’s important to understand the requirements of your lab or company to ensure that you buy the correct type of device. This includes homogenization method and components used to break apart substances.

Take into consideration the type of method best suited for your needs, as well as the size. Do you need a small handheld homogenizer, a benchtop homogenizer, or something bigger, fit for industrial and large-scale needs?

Let’s review some common methods.

Agitation, Impact, Stirring, and Shearing
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Mechanical homogenizers can utilize stainless steel blades, beads, or generator probes to break apart cells. Some instrument examples include:

  • Bead mill homogenizers
  • Rotor-stator homogenizers and blade homogenizers
  • High shear mixers and high shear homogenizers

Bead mill homogenizers, or bead mills, use small beads to agitate a sample and break it open in order to understand its intracellular contents.

Rotor-stator homogenizers, high shear mixers, and high speed dispersers use a rotating rotor and blades to draw a sample up through a stator with small holes, shearing the sample into very small particles.

Although blade homogenizers are less efficient, their simple design and use of blades allows for a wide variety of samples to be processed. Mechanical homogenizers have greatly improved the speed and quality of homogenization through updated speed control and digital displays.

 

High Pressure
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A high pressure homogenizer, or HPH, similar to but slightly different than its mechanical counterpart, uses pressure in order to lyse cells.

Shearing is achieved by passing a sample through a system that applies force in a number of ways, as the sample squeezes through a narrow opening, effectively disrupting the cellular bonds.

These machines can be used to modify microorganisms, create cost-effective drugs, and synthesize new chemicals.

 

Ultrasonic
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Ultrasonic treatment, also known as sonication or ultrasonication, is the method of applying sound to agitate cells or subcellular structures in suspension. This technique is used for the extraction of compounds from samples like seaweed, plants, and so much more.

By creating microbubbles within a sample, the cells eventually expand and burst open. These devices, known as ultrasonic homogenizers, are especially useful in the field of life sciences.

Cell fractionation is another method of homogenization, and is a term most commonly used in the biotech industry. This three-step process separates cellular components while preserving the individual function of each component. The steps are:

  • Extraction: Firstly, in order to maintain any biological activity, isolation must occur.
  • Homogenization: Once a cell or tissue is isolated in suspension, the cells are disrupted using homogenization. Accomplish by either grinding, osmotic shock, or some form of high pressure. Sometimes ultrasonication may even be used.
  • Centrifugation: After homogenization, separation (fractionation) of different components of the mixture is done with the use of a type of centrifuge called an ultracentrifuge. This device spins at extremely high speeds to generate force, separating small molecules from one another.
 

High-Shear Mixer Leases to Fit Every Need

three shapes shown one after another: an erlenmeyer flask, boiling flask, and graduated cylinder

High quality automated machinery makes any preparative task involving homogenizing, mixing, shaking, or vortexing easier. This includes lab homogenizers, mixers, shakers, stirrers, and more.

Whether you’re small or large scale laboratory, homogenizer equipment provides modern solutions to homogenization. It is a vital part of any laboratory concerned with throughput, reproducibility, and quality control.  

If budget is an issue, Excedr’s leasing program can provide a solution. We offer leasing options for a wide range of homogenization and mixing equipment for laboratory use through our lease program. Our program also includes preventative maintenance and repair coverage, so any unforeseen downtime you experience will be minimized. 

Reach out to us today and skip the large upfront costs associated with purchasing by leasing your laboratory equipment instead. If you have an instrument in mind, simply request a lease estimate to start the approval process.

Operating Lease

This off-balance sheet financing structure provides three options at the end of the term. The lessee has the option to return the equipment to the lessor, renew at a discounted rate, or purchase the instrument for the fair market value. Monthly payments are also 100% tax deductible which yields additional monetary savings.

Sale-Leaseback

If you recently bought equipment, Excedr can offer you cash for your device and convert your purchase into a long-term rental. This is called a sale leaseback. If you’ve paid for equipment within the last ninety days, we can help you recoup your investment and allow you to make low monthly payments. This also frees up money in your budget rather than tying it down to a fixed asset.


Laboratory Homogenizer Manufacturers & Models
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Cole-Parmer:
LabGEN 850, LabGEN 7, LabGEN 125, LabGEN 700

Thermo Fisher Scientific:
Homogenizer Laboratory Blender

Fisher Scientific: F
isherbrand Bead Mill 24, Fisherbrand Bead Mill 4, Fisherbrand 850

Qiagen:
TissueLyser II, TissueLyser LT, PowerLyzer 24

IKA:
magic LAB, Labor Pilot, Process Pilot, magic PLANT, ULTRA-TURRAX UTL, UTL Economy Line, HED, Dispax-Reactor DR, Dispax-Reactor DRS, MK (Colloid Mill), MKO (Cone Mill), Corundum Disk Mill (MCD)

Bio-Rad:
TeSeE PRECESS 24, TeSeE PRECESS 48

Benchmark Scientific:
D1000 Homogenizer, BEADBUG 3, BEADBUG 6, BEADBLASTER, BEADBLASTER 24R

PRO Scientific:
PRO25D, PRO400DS, PRO400DSEL, PRO400PC, PRO400PCEL, Multi-Prep Rapid Homogenizer, DPS-20 Dual Homogenizing System

MP Biomedicals:
FastPrep-24 Classic, FastPrep-24 5G, FastPrep 96, SuperFastPrep-2

Biotage:
Biotage Lysera

Omni International:
Bead Ruptor Elite, Bead Ruptor 12, Bead Ruptor 4, Bead Ruptor 96, Omni Mixer, Omni Macro, Omni Macro ES, Omni Sonic Ruptor 400, Omni Sonic Ruptor 4000, Omni Prep, Prep 96, LH 96, GLH 850, Omni Tissue TH, Omni THQ, Tissue Master 125, Omni Micro

Analytik Jena:
SpeedMill PLUS

SPEX SamplePrep LLC:
Geno/Grinder, 1600 MiniG, 2030 Geno/Grinder, 1200 GenoLyte

GEA Group:
XStream Lab Homogenizer 1000, XStream Lab Homogenizer 2000, Pilot Plant Homogenizer, Pony 2006, Panther 3006, Table-Top Homogenizer, PandaPLUS 1000, PandaPLUS 2000, TwinPANDA 400, TwinPANDA 600

 


Operating Capital Benefits

Operating Capital Benefits

Excedr's operating lease structure allows you to keep your business credit line open for expansions, staffing, and other operational expenses. Additionally, it strengthens the cash flow of your business and keeps cash reserves free for business development opportunities.

Effects on Credit

Effects on Credit

Leasing / renting provides you with non-dilutive financing and does not hinder your future borrowing ability. You're able to acquire the equipment you need without the baggage associated with traditional financing.

Used Equipment

Used Equipment

Unlike traditional financing and leasing companies, the Excedr program can accommodate refurbished/reconditioned equipment in addition to demo units. If you are looking for additional cost-savings, we recommend considering this option.

Speed of Approval

Speed of Approval

Excedr's program allows you to respond quickly as your need for equipment and technology arises. You can be approved with minimal documentation and have the equipment you need in operation and generating revenue for your business quickly.