How Cryogenic Freezers Work & How Leasing One Benefits Lab Managers

Excedr - Cryogenic Freezers

Despite the diversity in methods, the Excedr lease program can source all instrument types and accommodate any brand preferences your end-user might have. Request an estimate today and see how leasing can discount your cryogenic equipment.

All equipment brands/models are available

The Advantages of Excedr’s Cryopreservation Equipment Leasing Program:

  • Eliminates the upfront cost of purchasing equipment by spreading its cost over time
  • Minimizes equipment downtime with included complete repair coverage and preventive maintenance
  • Takes advantage of potentially 100% tax deductible* payments, providing you significant cash-savings
  • Expedites the administrative work needed for instrument procurement and logistics
  • Conserves working capital,  enabling you to reinvest in your core business and operations (staffing, inventory, marketing/sales, etc.)
  • Accommodates all manufacturer and model preferences

*Please consult your tax advisor to determine the full tax implications of leasing equipment.

a microplate well leaning against a graduated cylinder on top of glassware storage

Cryogenic freezers provide refrigeration solutions for life science research and clinical applications that require freezing at extremely low temperatures.

Unlike ultra-low temperature (ULT) freezers and traditional lab freezers, cryogenic freezers can maintain temperatures within the cryogenic temperature range, ranging between -150°C to absolute zero. This freezing method is referred to as cryopreservation. It applies to various fields that include cryosurgery, food sciences, ecology, plant physiology, biochemistry, molecular biology, and cryopreservation of cells, cell cultures and organs.

Many medical applications require samples to be frozen at cryogenic temperatures, such as blood transfusions, bone marrow transplantation, artificial insemination, and in vitro fertilization. Healthcare providers have greatly benefitted from the use of cryogenic freezers.

High-performance units utilize freezing and uniform temperatures for long-term storage, offering conditions ideal for preserving valuable biological material indefinitely. These metrics preserve, rather than fatally freeze, by preventing ice crystal formation, osmotic shock, and membrane damage. This allows the sample to return to the same viable state it was in before being frozen.

However, in the case of more sensitive mammalian cells, it is sometimes necessary to use specialized media or freezing reagents that can be applied to reduce freezing damage. These reagents include various cryoprotectants, such as glycerol or dimethyl sulfoxide (DMSO).

Improvements in cryogenics have resulted in better survival and high-quality functionality of human tissue and cell samples, permitting their successful use in future clinical applications.

Purchasing a cryogenic freezer can be difficult, as these units are often quite expensive. However, many laboratories—small startups, growing middle market, and large enterprise companies—have started relying on leasing as a viable alternative to purchasing.

This is due to Excedr’s ability to absorb the upfront costs for you and spread them out over low, manageable, recurring payments. Read on to learn more about these freezers and the benefits of cryopreservation.

Cryogenic Freezing & the Benefits of Cryopreservation

a hand face up balancing a screw on its index finger

Cryogenic freezers are relatively similar across makes and models, but can vary based on your preferred method of freezing, size of sample storage, and desired application.

To freeze samples, freezers generally employ liquid nitrogen (LN2) and other cryogenic liquids like liquid carbon dioxide (CO2) in the gas and vapor phase. However, mechanical compressors offer an economical alternative to the more costly freezing agents. Depending on your needs and field of work, you have some options.

Furthermore, cryogenic freezer design considers temperature uniformity, ergonomics, space requirements, and maneuverability, which means you should too. Consider the freezer’s configuration. Is an upright freezer optimal for your laboratory space? How about an under-counter model? Also, check whether the unit has casters for easy maneuvering and is configured to provide superior ergonomics and easy access.

How Gas u0026 Vapor Phase Liquid Nitrogen Freezers Work

Cryogenic freezers that employ gas and vapor-phase liquid nitrogen or other various cryogenic liquids to keep the unit at a low cryogenic temperature are designed explicitly for the long-term storage of precious samples in a cryogenic state. They can preserve the cell structure as a viable product upon thawing. Most models offer an optimal combination of liquid nitrogen consumption and storage stability.

The unit can be used in a liquid phase, gas phase, or dry phase and has a wide range of specifications:

  • Liquid nitrogen capacity: 40L-1800L
  • Quantity of vials (2ml): 7500-98000 units
  • Number of goblets for straws: 12-2000 units
  • Temperatures at or below: -150°C
  • Quantity of blood bags (DF700): 30-1000 units

For organization, freezers come equipped with external or internal racks and different options of neck size, from narrow to wide, to accommodate easy access. You can also organize your vials using fiberboard boxes with dividers made available by numerous manufacturers, such as Thermo Fisher Scientific.

Alternatively, you may consider acquiring a liquid nitrogen dewar. Dewars are used for liquid nitrogen storage and can safely distribute the freezing agent in small amounts throughout the unit. This is because their superior vacuum performance, insulation, and low LN2 consumption allow for optimal thermal efficiency and maximum holding times even under rugged conditions. These containers are an excellent option for short-term storage or transportation.

 

How Mechanical Cryo Freezers Work

These cryo freezers work without liquid nitrogen. Instead, they rely on a mechanical cooling system that often includes dual compressors, one acting as a fail-safe if the other happens to shut off.

Often referred to as chest freezers, these models offer a similar range of specifications to the LN2 freezers while being an economical alternative to costly coolants such as LN2.

These models can’t reach as low temperatures as the Liquid Nitrogen freezers. However, they do reach temperatures of -150°C and provide a viable solution to long-term freezing applications.

Although cryogenics applies to different fields of science, medicine, transportation, and food distribution, the introduction of cryogenics into freezing has opened up doors to the world of long-term preservation and cryopreservation.

Without reaching temperatures below -150°C using coolants like liquid nitrogen, cells and tissues could not be kept usable.

 

Defrosting Annually

It’s important to note that the freezer, regardless of how it is designed, should be defrosted at least once a year, or whenever ice buildup exceeds 1/4′”.

To defrost the freezer, you must first remove all the items and place them within another freezer. Then, turn the unit off, open the door or lid, and remove any sub-lids and racks. Let stand for 24 hours, allowing the ice to melt.

Afterward, you can wipe away any water standing in the bottom of the cabinet and clean the freezer if necessary. Lastly, reinstall any sub-lids, close the lid or door, and restart the freezer. Once it’s back to the desired temperature, you can replace the items.

 

Liquid Nitrogen & Cryogenic Leases to Fit Every Need

three shapes shown one after another: an erlenmeyer flask, boiling flask, and graduated cylinder

Whether you’re looking to lease a cryogenic freezer, ultra-low temperature freezer, or laboratory freezer, we’ve got you covered. 

Fill out our contact form online or give us a call at (510) 982-6552, and we can get you on the road to flexible financing in no time.

Operating Lease

This off-balance sheet financing structure provides three options at the end of the term. The lessee has the option to return the equipment to the lessor, renew at a discounted rate, or purchase the instrument for the fair market value. Monthly payments are also 100% tax deductible which yields additional monetary savings.

Sale-Leaseback

If you recently bought equipment, Excedr can offer you cash for your device and convert your purchase into a long-term rental. This is called a sale-leaseback. If you’ve paid for equipment within the last ninety days, we can help you recoup your investment and allow you to make low monthly payments. This also frees up money in your budget rather than tying it down to a fixed asset.

Cryogenic Freezer Manufacturers u0026 Models
Learn More

ThermoFisher Scientific:
Cryogenic Storage Chest Freezer, CryoMed Controlled-Rate Freezers

Abeyance Cryo Solutions:
Abeyance Cryo Freezers, A220, A4040, A700, A1000, Extended Height Cryo Freezers, E264, E528, E840, E1200

Custom Biogenic Systems:
V15000-AB, V-3000AB, V-3000EH-AB, V-5000EH-AB, V-5000AB, V-3000AB-C, V-3000EHAB-C, V-5000AB-C, V-5000EHAB-C, S-90AB, S-1500AB, S-3000AB, S-5000AB, S-5000EH-AB, S-3000EH-AB, V-1500SS, V-3000SS

PHCBI, PHC Corporation of North America:
MDF-1156 MDF-C2156VANC-PA

Worthington Industries:
LABS Series Cryostorage Freezer Systems, K Series Cryostorage Freezer Systems, XT/AI series, XTL3, XT10, XTL8/XT20, XT34, XT21/AI21, XT24/AI24, HC Series, HCL12/HC20, HC34/HC35/VHC35/HC38/VHC38, LS Series, LS750, LS3000/LS4800/LS6000, Worthington RoboStor

Celltrio:
Celltrio MC Series, Celltrio RoboStor Series

Chart Industries:
Stainless Steel Cryogenic Freezers, MVE Fusion Series, MVE Automation Series, MVE HEco 800 Series, MVE HEco 1500 Series, MVE HEco 1800 Series, MVE High Efficiency 800 Series, MVE High Efficiency 1500 Series, MVE High Efficiency 1800 Series, MVE Vario 1500 Series, MVE Vario 1800 Series, MVE Series

Planer Limited:
Kryo 360, Kryo 560, Kryo 750, Kryo 1060

and more!

 

Operating Capital Benefits

Operating Capital Benefits

Excedr's operating lease structure allows you to keep your business credit line open for expansions, staffing, and other operational expenses. Additionally, it strengthens the cash flow of your business and keeps cash reserves free for business development opportunities.

Effects on Credit

Effects on Credit

Leasing / renting provides you with non-dilutive financing and does not hinder your future borrowing ability. You're able to acquire the equipment you need without the baggage associated with traditional financing.

Used Equipment

Used Equipment

Unlike traditional financing and leasing companies, the Excedr program can accommodate refurbished/reconditioned equipment in addition to demo units. If you are looking for additional cost-savings, we recommend considering this option.

Speed of Approval

Speed of Approval

Excedr's program allows you to respond quickly as your need for equipment and technology arises. You can be approved with minimal documentation and have the equipment you need in operation and generating revenue for your business quickly.