How Surface Plasmon Resonance Works & How We Save You Time & Money
Ultimately the Excedr lease program can accommodate your lab’s instrument needs and brand/model preferences. Get in touch with us today and see how leasing can save you time and money on your SPRI research platform.
All equipment brands/models are available
The Advantages of Excedr’s SPRI Instrument Leasing Program:
- Eliminates the upfront cost of purchasing equipment by spreading its cost over time
- Minimizes equipment downtime with included complete repair coverage and preventive maintenance
- Takes advantage of potentially 100% tax deductible* payments, providing you significant cash-savings
- Expedites the administrative work needed for instrument procurement and logistics
- Conserves working capital, enabling you to reinvest in your core business and operations (staffing, inventory, marketing/sales, etc.)
- Accommodates all manufacturer and model preferences
*Please consult your tax advisor to determine the full tax implications of leasing equipment.
Observing how a chemical substance or biological ligand interacts with a transducer can be referred to as biosensing.
Surface plasmon resonance imaging (SPRI) is a high throughput optical biosensing technique used to study small molecules and provide data on the affinity, specificity, and kinetics of biomolecular interactions.
It is also referred to as surface plasmon resonance microscopy (SPRM) and provides its data by measuring the target molecules’ real-time binding association rates and dissociation rates. It is considered a fundamental principle behind many biosensor applications, diatom photosynthesis, and various lab-on-a-chip sensors.
Surface Plasmon Resonance (SPR) technology is combined with imaging devices to form SPRI and can be used in several different ways.
It is most commonly used to analyze molecular interactions because, unlike many other immunoassays, such as ELISA, SPR assays allow for real-time, label-free detection of biomolecular interactions and provide higher-throughput analysis than many traditional methods.
Surface plasmon resonance is also used for measuring the adsorption onto the surface of metal nanoparticles or onto a planar metal surface (such as gold or silver), as it is the basis behind many other tools that material adsorption onto planar metal. This includes using SPR as a characterization tool for lipid nanoparticles (LNPs) used in drug discovery.
Other SPR applications include observing protein-to-protein, protein-to-antibody, DNA-to-protein, and many other molecular exchanges. Unlike similar analytical techniques, SPR can be used to look at both binding kinetics and binding affinity.
A plasmon refers to the minimum amount, or quantum, of rapid oscillations of electron densities in conducting medium or plasma densities. Surface plasmon relates to this oscillation as it occurs on the surface of a conducting medium such as a metallic surface.
When polarized light hits an electrically conducting surface, such as a metal, some light is absorbed by the object’s surface electrons and resonates with the electrons along the material’s surface. Specifically, it occurs at the interface of the media with different refractive indices. These resonated electrons are the surface plasmons.
Surface plasmon resonance excites electrons on the surface of a conductive layer and detects the resulting oscillations of free electrons. This means that the excited electrons absorb some of the incident light, and the resulting reflected light will now contain an absorption line. This absorption line can then be used to determine various qualities of the material.
SPR Instrumentation, Techniques, & Methods
Though the critical components of SPR instrumentation are similar across all types, the modes of excitation vary. Three of the most commonly used methods include the Kretschmann-Raether configuration, Otto configuration, and grating coupled.
In addition to these methods, another important method has been developed as a hybrid method in which electrochemistry and SPR is combined to create a novel SPR technique. It is referred to as electrochemical SPR (ESPR).
Possible Early Detection of Cancer
Surface Plasmon Resonance Instrument Leases to Fit Every Need
Whether you’re interested in surface plasmon resonance or western blot, we can help you finance either system. Give us a call at +1 888-927-3802 or fill out our contact form to learn more about how we can help you achieve your goals.
This off-balance sheet financing structure provides three options at the end of the term. The lessee has the option to return the equipment to the lessor, renew at a discounted rate, or purchase the instrument for the fair market value. Monthly payments are also 100% tax deductible which yields additional monetary savings.
If you recently bought equipment, Excedr can offer you cash for your device and convert your purchase into a long-term rental. This is called a sale-leaseback. If you’ve paid for equipment within the last ninety days, we can help you recoup your investment and allow you to make low monthly payments. This also frees up money in your budget rather than tying it down to a fixed asset.