Surface Plasmon Resonance Instrument:

Surface Plasmon Resonance Instrument

How Surface Plasmon Resonance Works & How We Save You Time & Money

Ultimately the Excedr lease program can accommodate your lab’s instrument needs and brand/model preferences. Get in touch with us today and see how leasing can save you time and money on your SPR machine.

All equipment brands/models are available

Here are the advantages of Excedr’s SPR instrument leasing program:

  • Spreading out payments over time eliminates the upfront cost of equipment purchases
  • Payments may be 100% tax deductible*, which yields you significant cash-savings
  • Purchase equipment outright  is more expensive than our leasing
  • Our comprehensive repair coverage minimizes your lab’s downtime
  • We handle the administrative work that comes along with equipment procurement and upkeep
  • With the capital saved through our program, labs are better able to reinvest in their core business and operations (staffing, inventory, marketing/sales, etc.)

*Please consult your tax advisor to determine the full tax implications of leasing equipment.

Observing how a chemical substance or biological ligand interacts with a transducer can be referred to as biosensing.

Surface plasmon resonance is an optical biosensing technique. Surface plasmon resonance, or SPR, are important tools used for analysis of molecular interactions. SPR allows for real-time, label-free detection of biomolecular interactions. An analytical process is considered label-free when it does not “label” any proteins by using isotopes that chemically bind to them during the procedure. SPR is a useful tool for measuring the adsorption onto the surface of metal nanoparticles or onto a metal surface such as gold or silver. It is also used in color-based biosensing, diatom photosynthesis, and lab-on-a-chip sensors. Other uses include observing protein to protein, protein to antibody, DNA to protein, and many other molecular exchanges. Unlike similar analytical techniques, SPR can be used to look at both binding kinetics and binding affinity. 

A plasmon refers to the minimum amount, or quantum, of rapid oscillations of electron densities in conducting medium or plasma densities. Surface plasmon relates to this oscillation as it occurs on the surface of a conducting medium such as a metallic surface. When polarized light hits an electrically conducting surface, such as a metal, some of the light is absorbed by the object’s surface electrons and resonates with the electrons along the material’s surface. Specifically, it occurs at the interface of the media with different refractive indices. These resonated electrons are the surface plasmons. Surface plasmon resonance excites electrons on the surface of a conductive layer and detects the resulting oscillations of free electrons. What this means is that the excited electrons absorb some of the incident light and the resulting reflected light will now contain an absorption line. This absorption line can then be used to determine various qualities of the material.

Surface Plasmon Resonance (SPR) Techniques, Methods, & Cost

Though the basic set-up of surface plasmon resonance is similar across all types, the modes of excitation vary. The three most common methods are the Kretschmann-Raether configuration, Otto configuration, and grating couplers.

Kretschmann-Raether Configuration
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This method uses an electrically insulated or dielectric prism, which is why it is considered a prism-based SPR system. A thin, metallic film and the analyte to be observed are put onto the prism. When the polarized light is shown through the prism at a specific angle, called the resonant angle, surface plasmon electromagnetic waves occur. These waves are also called surface plasmon polariton. Due to the fact that the metallic layer is placed directly on the prism, this technique allows for more efficient plasmon wave generation.

 

Otto Configuration
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Similar to the Kretschmann-Raether configuration, Otto configuration consists of a dielectric prism, metallic film, and an analyte. The difference is that the analyte and the metallic film are not attached to the prism. Between the prism and the conductive layers, there is a thin gap of air or another low index spacer. The light in the prism is internally reflected and an evanescent wave is created within the air gap. This wave excites the surface plasmon and creates surface plasmon polaritons. This technique is often used to look at SPR in solid-phase mediums.

 

Grating Couplers
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First introduced in 1983, grating couplers use the physical phenomenon of diffraction grating rather than a prism. Diffraction grating is an optical technique that is able to disperse light of many different wavelengths, such as white light and diffracts each wavelength at a different angle. This diffraction is accomplished by having the light strike a grating plate which has grooves that are at specific depths and intervals. In SPR this grating plate is covered with a conductive metal like gold or silver and the angle of the light is dependent on the biomolecules on the outside of the grating. By varying the angle of the incident light and capturing the resulting reflected light, a binding curve can be formed and information about the molecules can be determined.

 

Possible Early Detection of Cancer
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Early detection of any serious disease is an important first step in a patient’s treatment. The earlier the diagnosis, the quicker you can begin to receive treatment. In January of 2019, Monash University announced that they developed a new method for early detection of cancer. Associate Professor Qiaoliang Bao along with other researchers, found a new material that has improved sensitivity in spotting cancerous molecules in DNA and MicroRNA. Their team used antimonene materials to develop a surface plasmon resonance sensor that identified biomarkers MicroRNA-21 and MicroRNA-155. This relatively low-cost and non-destructive testing could alert people whether or not they have cancer, making proactive treatment feasible.

 

Whether you’re interested in surface plasmon resonance or western blot, we can help you finance either system. Give us a call at (510) 982-6552 or fill out our contact form to learn more about how we can help you achieve your goals.

We Offer Surface Plasmon Resonance Instrument Leases to Fit Every Need

Operating Lease

This off-balance sheet financing structure provides three options at the end of the term. The lessee has the option to return the equipment to the lessor, renew at a discounted rate, or purchase the instrument for the fair market value. Monthly payments are also 100% tax deductible which yields additional monetary savings.

Sale-Leaseback

If you recently bought equipment, Excedr can offer you cash for your device and convert your purchase into a long-term rental. This is called a sale-leaseback. If you’ve paid for equipment within the last ninety days, we can help you recoup your investment and allow you to make low monthly payments. This also frees up money in your budget rather than tying it down to a fixed asset.


Surface Plasmon Resonance Instrument Manufacturers & Models on the Market
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GE Healthcare Life Sciences:
Biacore 8K+, Biacore 8K, Biacore S200, Biacore T200, Biacore X100, Biacore X100 Plus Package, Biacore C

Horiba:
OpenPlex, XelPlex, SPRi-CFM, SPRi-Arrayer

Biosensing Instruments:
SPRm 200 Series, BI-4500 Series, BI-2500 Series

Bio-Rad:
ProteOn System, ProteOn XPR36

Reichert Technologies:
4SPR, 2SPR

ForteBio:
Pioneer FE System, Pioneer FE SPR System

Bruker:
Sierra SPR-32

BiOptix Analytical:
404pi

Carterra:
LSA

Plasmetrix:
CORgI I, CORgI II, CORgI SD, CORgI ID, SpectraCube LSPR System

BioNavis:
MP-SPR Navi, 420A ILVES, 220A NAALI, 210A VASA, 200 OTSO

Nano SPR:
NanoSPR6, NanoSPR8, NanoSPR9, NanoSPR103

Plexera:
PlexArray HT System

Nicoya Lifesciences:
OpenSPR, OpenSPR-XT

Affinite Instruments:
P4SPR

IBIS Technologies:
IBIS-MX96, SensEye Sensor

and more!

 


Operating Capital Benefits

Operating Capital Benefits

Excedr's operating lease structure allows you to keep your business credit line open for expansions, staffing, and other operational expenses. Additionally, it strengthens the cash flow of your business and keeps cash reserves free for business development opportunities.

Effects on Credit

Effects on Credit

Leasing / renting provides you with non-dilutive financing and does not hinder your future borrowing ability. You're able to acquire the equipment you need without the baggage associated with traditional financing.

Used Equipment

Used Equipment

Unlike traditional financing and leasing companies, the Excedr program can accommodate refurbished/reconditioned equipment in addition to demo units. If you are looking for additional cost-savings, we recommend considering this option.

Speed of Approval

Speed of Approval

Excedr's program allows you to respond quickly as your need for equipment and technology arises. You can be approved with minimal documentation and have the equipment you need in operation and generating revenue for your business quickly.