Surface Plasmon Resonance Instrument
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Observing how a chemical substance or biological ligand interacts with a transducer can be referred to as biosensing. Surface plasmon resonance is an optical biosensing technique. Surface plasmon resonance, or SPR, are important tools used for analysis of molecular interactions. SPR allows for real-time, label-free detection of biomolecular interactions. An analytical process is considered label-free when it does not “label” any proteins by using isotopes that chemically bind to them during the procedure. SPR is a useful tool for measuring the adsorption onto the surface of metal nanoparticles or onto a metal surface such as gold or silver. It is also used in color-based biosensing, diatom photosynthesis, and lab-on-a-chip sensors. Other uses include observing protein to protein, protein to antibody, DNA to protein, and many other molecular exchanges. Unlike similar analytical techniques, SPR can be used to look at both binding kinetics and binding affinity.
A plasmon refers to the minimum amount, or quantum, of rapid oscillations of electron densities in conducting medium or plasma densities. Surface plasmon relates to this oscillation as it occurs on the surface of a conducting medium such as a metallic surface. When polarized light hits an electrically conducting surface, such as a metal, some of the light is absorbed by the object’s surface electrons and resonates with the electrons along the material’s surface. Specifically, it occurs at the interface of the media with different refractive indices. These resonated electrons are the surface plasmons. Surface plasmon resonance excites electrons on the surface of a conductive layer and detects the resulting oscillations of free electrons. What this means is that the excited electrons absorb some of the incident light and the resulting reflected light will now contain an absorption line. This absorption line can then be used to determine various qualities of the material.
Surface Plasmon Resonance (SPR) Techniques, Methods, & Cost
Though the basic set-up of surface plasmon resonance is similar across all types, the modes of excitation vary. The three most common methods are the Kretschmann-Raether configuration, Otto configuration, and grating couplers.
This method uses an electrically insulated or dielectric prism, which is why it is considered a prism-based SPR system. A thin, metallic film and the analyte to be observed are put onto the prism. When the polarized light is shown through the prism at a specific angle, called the resonant angle, surface plasmon electromagnetic waves occur. These waves are also called surface plasmon polariton. Due to the fact that the metallic layer is placed directly on the prism, this technique allows for more efficient plasmon wave generation.
Similar to the Kretschmann-Raether configuration, Otto configuration consists of a dielectric prism, metallic film, and an analyte. The difference is that the analyte and the metallic film are not attached to the prism. Between the prism and the conductive layers, there is a thin gap of air or another low index spacer. The light in the prism is internally reflected and an evanescent wave is created within the air gap. This wave excites the surface plasmon and creates surface plasmon polaritons. This technique is often used to look at SPR in solid-phase mediums.
First introduced in 1983, grating couplers use the physical phenomenon of diffraction grating rather than a prism. Diffraction grating is an optical technique that is able to disperse light of many different wavelengths, such as white light, and diffracts each wavelength at a different angle. This diffraction is accomplished by having the light strike a grating plate which has grooves that are at specific depths and intervals. In SPR this grating plate is covered with a conductive metal like gold or silver and the angle of the light is dependent on the biomolecules on the outside of the grating. By varying the angle of the incident light and capturing the resulting reflected light, a binding curve can be formed and information about the molecules can be determined.
Cancer Diagnosis & SPR
Early detection of any serious disease is an important first step in a patient’s treatment. The earlier the diagnosis, the quicker you can begin to receive treatment. In January of 2019, Monash University announced that they developed a new method for early detection of cancer. Associate Professor Qiaoliang Bao along with other researchers, found a new material that has improved sensitivity in spotting cancerous molecules in DNA and MicroRNA. Their team used antimonene materials to develop a surface plasmon resonance sensor that identified biomarkers MicroRNA-21 and MicroRNA-155. This relatively low-cost and non-destructive testing could alert people whether or not they have cancer, making proactive treatment feasible.
As an optical analytical tool, SPR instruments are indispensable. Don’t let their onerous upfront cost prevent you from acquiring one for your lab. With Excedr’s leasing program you can finance your device and have peace of mind with our comprehensive maintenance coverage. Contact us today to learn more!
We Offer SPR Instrument Leases to Fit Every Need
This off-balance sheet financing structure provides three options at the end of the term. The lessee has the option to return the equipment to the lessor, renew at a discounted rate, or purchase the instrument for the fair market value. Monthly payments are also 100% tax deductible which yields additional monetary savings.
If you recently bought equipment, Excedr can offer you cash for your device and convert your purchase into a long-term rental. This is called a sale leaseback. If you’ve paid for equipment within the last ninety days, we can help you recoup your investment and allow you to make low monthly payments. This also frees up money in your budget rather than tying it down to a fixed asset.
LOCALIZED SURFACE PLASMON RESONANCE INSTRUMENT MANUFACTURERS & MODELS ON THE MARKET
- Cytiva (formerly GE Healthcare Life Sciences): Biacore 8K+, Biacore 8K, Biacore S200, Biacore T200, Biacore X100, Biacore
- Horiba: OpenPlex, XelPlex, SPRi-CFM, SPRi-Arrayer
- ForteBio: OneStep, Pioneer, Pioneer FE
- Bio-Rad: ProteOn XPR36
- Carterra: LSA
- Nicoya Lifesciences: OpenSPR, OpenSPR-XT, Alto
- Biosensing Instrument: SPRM200 Series, BI-4500 Series, BI-2500 Series
- Reichert Technologies: 4SPR, 2SPR
- Bruker: Sierra SPR-32. Sierra SPR-24 Pro
- BiOptix Analytical: 404pi
- Plasmetrix: CORGI I, CORGI II, CORGI IFF, CORGI C_CUBE
- BioNavis: 420A ILVES, 220A NAALI, 210A VASA, 400 KONITO, 200 OTSO
- Nano SPR: NanoSPR6, NanoSPR8, NanoSPR9, NanoSPR103
- Plexera: PlexArray HT System
- and more!
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Effect on Credit & Operating Capital
Leasing/renting does not hinder your future borrowing ability and allows you to keep your business credit line open for expansions, staffing, and other operational expenses. Additionally, it strengthens the cash flow of your business and keeps cash reserves free for business development opportunities.
Unlike traditional financing and leasing companies, the Excedr program can accommodate refurbished/reconditioned equipment in addition to demo units. If you are looking for additional cost-savings, we recommend considering this option.
Speed of Approval
Excedr’s program allows you to respond quickly as your need for equipment and technology arises. You can be approved with minimal documentation and have the equipment you need in operation and generating revenue for your business quickly.
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If you’re looking to acquire new equipment be it an SPR instrument or leasing a nucleic acid and protein purification device our program can help you. Get in touch with us at +1(510) 982-6552 or fill out our contact form above and we can discuss your needs in depth.