How a Peptide Synthesizer Works & How We Save You Time & Money
Despite the diversity in types, the Excedr lease program is able to source all instrument types and can accommodate any brand preferences your end-user might have. Request an estimate today and see how leasing can affect your automated peptide synthesizer’s price.
All equipment brands/models are available
The Advantages of Excedr’s Peptide Synthesizer Leasing Program:
- Eliminates the upfront cost of purchasing equipment by spreading its cost over time
- Minimizes equipment downtime with included complete repair coverage and preventive maintenance
- Takes advantage of potentially 100% tax deductible* payments, providing you significant cash-savings
- Expedites the administrative work needed for instrument procurement and logistics
- Conserves working capital, enabling you to reinvest in your core business and operations (staffing, inventory, marketing/sales, etc.)
- Accommodates all manufacturer and model preferences
*Please consult your tax advisor to determine the full tax implications of leasing equipment.
Solid-phase peptide synthesis (SPPS) has enabled the creation of synthetic peptides, which has revolutionized organic chemistry and significantly benefited biomedical research.
It was pioneered by Bruce Merrifield throughout the late 1950s and early 1960s. His technique presented a simple method for the chemical synthesis of peptides and proteins, accomplished by synthesizing peptides opposite of how we synthesize peptides in our body.
In our body, ribosomes build proteins by beginning at the amino-terminal (N-terminus) and ending at the carboxyl-terminal (C-terminus). However, using Merrifield’s technique, the opposite occurs (C-to-N).
Using his method, researchers could now assemble a peptide chain through successive reactions of amino acid derivatives on various insoluble and permeable supports, typically made of multiple resins such as polystyrene. Since SPPS’s introduction, peptide research has grown exponentially.
Moreover, SPPS led to the development of automated peptide synthesizers. These machines drastically simplified and expedited the production of both small peptides and large proteins, a task that was once aggravatingly tedious. Suddenly, preparing multiple peptide samples at once was much easier and faster.
Despite the technique’s success, several peptide researchers remained quite critical after its introduction and adoption. These critiques focused on its application to larger and larger molecules. Researchers felt that a technique that prevented the full characterization of synthetic intermediates could not give rise to authentic peptide products.
Nonetheless, Merrifield—and several other laboratories—continued to develop the method and eventually quieted the objections by improving solid-phase peptide synthesis as a technique. In research today, the definition and input of the synthesis strategy and the amino acid sequence are all that is required to perform synthesis.
Peptide synthesis has invigorated the development of different application areas where synthetic peptides are now used, including the study of protein functions, the identification and characterization of proteins, and the development of epitope-specific antibodies against pathogenic proteins. This technique also offers a range of uses in the medical and research fields, including acting as chemical messengers, inter and intra-cellular mediators, hormones, and much more.
Its processes, benefits, and costs are important considerations when looking to procure a laboratory automated peptide synthesizer.
Synthesizer Process, Benefits, & Cost
These systems allow researchers, medical professionals, and many others to create the specific proteins and peptides they need with tremendous ease. In general, there are several parts to synthesizing peptides, including resin swelling, peptide deprotection, amino acid coupling, and peptide cleavage.
Swelling the Resin
Amino Acid Coupling
Protein Synthesis Strategies
Customized Protein Synthesizer Leases to Fit Every Need
Thanks to developments in biotechnology and bioengineering, the interest in peptide synthesis has increased, and researchers in the life sciences are using peptide synthesis and chemistry to further their work involving the study of protein molecules and their functions. This also includes antibody production, antibiotic drug development, vaccine production and design, and cancer diagnosis and treatment.
If you’re interested in leasing a peptide synthesizer, or any another instrument used in protein research, such as a microarray scanner, let us know. We can help you procure the equipment you need to get the job done.
Fill out our contact form or give us a call at (510) 982-6552 and we can discuss your specific needs in-depth.
This off-balance sheet financing structure provides three options at the end of the term. The lessee has the option to return the equipment to the lessor, renew at a discounted rate, or purchase the instrument for the fair market value. Monthly payments are also 100% tax deductible which yields additional monetary savings.
If you recently bought equipment, Excedr can offer you cash for your device and convert your purchase into a long-term rental. This is called a sale-leaseback. If you’ve paid for equipment within the last ninety days, we can help you recoup your investment and allow you to make low monthly payments. This also frees up money in your budget rather than tying it down to a fixed asset.