How PCR Systems Work & How We Save You Time & Money
Despite the diversity in methods, the Excedr lease program is able to source all instrument types and can accommodate any brand preferences your end-user might have. Request an estimate today and see how leasing can discount your PCR system or thermal cycler’s price.
All equipment brands/models are available
The Advantages of Excedr’s PCR System Leasing Program:
- Eliminates the upfront cost of purchasing equipment by spreading its cost over time
- Minimizes equipment downtime with included complete repair coverage and preventive maintenance
- Takes advantage of potentially 100% tax deductible* payments, providing you significant cash-savings
- Expedites the administrative work needed for instrument procurement and logistics
- Conserves working capital, enabling you to reinvest in your core business and operations (staffing, inventory, marketing/sales, etc.)
- Accommodates all manufacturer and model preferences
*Please consult your tax advisor to determine the full tax implications of leasing equipment.
Polymerase chain reaction (PCR) is used to amplify nucleic acids in vitro using DNA sequences as primers that help select the segment of the genome to be amplified.
PCR amplification is considered a high-throughput technique and is widely used for applications in the life sciences, such as molecular biology (functional genomics in particular), microbiology, genetics, pharmaceutical research, diagnostics, clinical laboratories, forensic science, environmental science, food science, hereditary studies, and paternity testing.
Despite revolutionizing scientific research, the basic principles of polymerase chain reaction are elegantly simple and involve a three-step reaction of thermal denaturation, primer annealing, and primer extension.
Thermal cyclers, or thermocyclers, facilitate this reaction and provide a thermally controlled environment for the PCR samples by changing the temperature of its heating block at specific times and by spending durations of time at specific temperatures. Thermal cyclers are also referred to as PCR systems, PCR machines, or DNA amplifiers
Once temperature cycling is complete, PCR amplification results are confirmed using agarose gel electrophoresis. Although DNA can be quantified during endpoint analysis, it is generally considered more reliable to do this using real-time PCR (qPCR).
Besides qPCR, there are a number of modified PCR techniques used in labs today. Each presents its own advantages and limitations, so it’s important to review the basics of the most common methods used before leasing a PCR machine.
Methods, Configurations, PCR Instrument Quantifications, & Costs
There are many variations of the original polymerase chain reaction method that have been developed over the years, and consequently, a wide variety of PCR machines and methods are available.
In addition to the three main steps of denaturation, primer annealing, and primer extension, several core ingredients are required regardless of method. These include template DNA, PCR buffer, DNA nucleotides, PCR primers, and thermostable DNA polymerase, or Taq polymerase.
Reverse Transcription (RT-PCR)
We Offer QPCR System Leases to Fit Every Need
If you’re interested in leasing a PCR system specifically for qPCR, RT-PCR, or ddPCR, we can help. Furthermore, we are brand agnostic and can accommodate any brand preference, whether it be Applied Biosystems, Bio-Rad, or Agilent.
Additionally, we lease a wide variety of biotechnology equipment, so if you need to complete a workflow by leasing other equipment, such as a nucleic acid extraction system, our lease program can assist.
You can reach us at +1 888-927-3802, or complete our contact form to specify your financing needs.
This off-balance sheet financing structure provides three options at the end of the term. The lessee has the option to return the equipment to the lessor, renew at a discounted rate, or purchase the instrument for the fair market value. Monthly payments are also 100% tax deductible which yields additional monetary savings.
If you recently bought equipment, Excedr can offer you cash for your device and convert your purchase into a long-term rental. This is called a sale leaseback. If you’ve paid for equipment within the last ninety days, we can help you recoup your investment and allow you to make low monthly payments. This also frees up money in your budget rather than tying it down to a fixed asset.