How DNA Synthesis Works & How We Save You Time & Money

The Advantages of Excedr’s DNA, RNA, and Oligo Synthesizer Leasing Program:

• Eliminates the upfront cost of purchasing equipment by spreading its cost over time
• Minimizes equipment downtime with included complete repair coverage and preventive maintenance
• Takes advantage of potentially 100% tax deductible* payments, providing you significant cash-savings
• Expedites the administrative work needed for instrument procurement and logistics
• Conserves working capital,  enabling you to reinvest in your core business and operations (staffing, inventory, marketing/sales, etc.)
• Accommodates all manufacturer and model preferences

*Please consult your tax advisor to determine the full tax implications of leasing equipment.

Oligonucleotide synthesizers give scientists the ability to create custom nucleic acid samples for various applications in science. 

DNA molecules are some of the most important molecules in biology and their creation, both natural and artificial, is studied and widely used in many scientific fields.

In general, natural DNA synthesis occurs by first having the gene split and create a second identical DNA strand in a process called DNA replication. Enzymes unwind the DNA strand and split it apart, creating a replication fork. When the cell divides, it creates a duplicate genome, ensuring the new cell has a complete set of chromosomes.

Specific proteins are then used to aid in the replication and synthesis of the new genetic strands. These helper proteins are called primers. RNA primers are the only naturally occurring primers, however, artificial synthesis can use both RNA and DNA primers.

A major difference between natural and synthetic DNA synthesis is that in natural synthesis the enzymes can only synthesize in one direction whereas artificial synthesis does not have this directional limitation. Additionally, artificial gene synthesis is based on solid-phase DNA Synthesis.

Oligonucleotide synthesis is the artificial chemical process of creating short strands of nucleic acids with specific sequences. Synthetic DNA printing differs from molecular cloning and polymerase chain reaction (PCR) because it does not require a pre-existing gene sequence.

DNA oligo synthesis is done by adding one nucleotide to the end of the desired chain at a time. Each addition is referred to as a synthetic cycle, or the phosphoramidite method, and undergoes four steps:

1. De-blocking (detritylation)
2. Coupling
3. Capping
4. Oxidation

There are various techniques and applications involved in DNA synthesis that provide high-quality results, some of which will we cover below.

Making custom gene sequences has helped advance many different fields of science, from biotechnology and microbiology to synthetic biology. DNA synthesizers have made many of the recent advances in synthetic oligonucleotide production possible.

A few other synthesis applications include vaccine research, molecular engineering, designing of new protein functions, and gene expression and therapy.

DNA and RNA synthesis are vital parts of cellular biology and our continued understanding of the world around us. That’s because these types of oligonucleotide synthesis help provide treatment to several diseases.

As oligonucleotide therapeutics continue to evolve, your lab may already be working with or plan on working with oligos. However, automated DNA and RNA synthesizers, can be incredibly expensive, and acquiring one can put labs in financially difficult situations.

Excedr offers labs a perfect alternative to purchasing which can help you save money and give you access to the vital technology that your lab needs.

Furthermore, if your work involves other types of synthesis, such as peptide synthesis, we can lease you and your lab the exact peptide synthesizer you require. Let us know if this is another piece of equipment you’re interested in.

Operating Lease

This off-balance sheet financing structure provides three options at the end of the term. The lessee has the option to return the equipment to the lessor, renew at a discounted rate, or purchase the instrument for the fair market value. Monthly payments are also 100% tax deductible which yields additional monetary savings.

Sale-Leaseback

If you recently bought equipment, Excedr can offer you cash for your device and convert your purchase into a long-term rental. This is called a sale-leaseback. If you’ve paid for equipment within the last ninety days, we can help you recoup your investment and allow you to make low monthly payments. This also frees up money in your budget rather than tying it down to a fixed asset.