How Capillary Electrophoresis Works & How We Save You Time & Money
Despite the diversity in methods, the Excedr lease program is able to source all instrument types and can accommodate any brand preferences your end-user might have. Request an estimate today and see how leasing can discount your CE/MS instrument price.
All equipment brands/models are available
The Advantages of Excedr’s CE Instrument Leasing Program:
- Eliminates the upfront cost of purchasing equipment by spreading its cost over time
- Minimizes equipment downtime with included complete repair coverage and preventive maintenance
- Takes advantage of potentially 100% tax deductible* payments, providing you significant cash-savings
- Expedites the administrative work needed for instrument procurement and logistics
- Conserves working capital, enabling you to reinvest in your core business and operations (staffing, inventory, marketing/sales, etc.)
- Accommodates all manufacturer and model preferences
*Please consult your tax advisor to determine the full tax implications of leasing equipment.
Capillary electrophoresis (CE) is an electrophoretic technique for separating and identifying charged molecules, such as amino acids, peptides, nucleic acids, and proteins.
It can also be used to separate various drugs based on their rate of migration through a given medium.
CE is part of a family of related techniques that use very narrow capillaries and buffers to perform high-efficiency electrophoretic separation of both small and large molecules. The separations occur through the use of high voltages, which creates electroosmotic flow (EOF) within the buffer solutions and ions inside the capillary tubing.
EOF is considered the driving force behind capillary electrophoresis, and results in the simultaneous analysis of anions, cations, and neutral charged molecules in a single analysis.
CE shares characteristics with traditional polyacrylamide gel electrophoresis (PAGE) and high-performance liquid chromatography (HPLC). In fact, CE and gel electrophoresis (GE) are considered to be in the same family. But, CE is generally seen as the faster method, providing higher throughput and resolution because the thin tubing used offer a higher surface-to-volume ratio than gels.
In contrast to the slab gels used in GE, capillary electrophoresis systems and instruments utilize these thin capillary tubes, or silica capillaries, to speed up the electrophoretic process. The tube can dissipate heat more quickly as well, allowing for higher voltages to run without any risk of overheating.
The high-voltage environment increases the velocity at which a molecule passes through the capillary, shortening the separation process and making CE highly efficient.
As well, capillary electrophoresis uses modern data acquisition devices to observe the ions as they pass through the capillary past the detector. The signal is recorded and sent to a computer with software for digital collection and analysis. The device requires very little amounts of a sample to work, so you can potentially save more money when using high-cost materials.
Furthermore, many capillary electrophoresis instruments are automated, consume limited amounts of reagents, offer precise quantitative analysis, and process a larger variety of analytes in comparison to other separation techniques. The automation is seen as advantageous to any laboratory that works with high-cost materials and is concerned with efficiency and high-resolution.
Below are the basic CE instrument components, as well as the common applications of capillary electrophoresis.
Components, Flow methods, & Electrophoresis Techniques
CE systems and instruments are used in a variety of fields and industries, including biomedicine, forensic sciences, chemistry, and pharmaceuticals. In biomedicine, CE has been extremely useful tool for separating and characterizing synthetic polymers, specifically biopolymers over the past two decades.
However, CE has perhaps had the greatest impact in clinical laboratories, helping with applications including:
- Protein analysis of proteins in serums, urine, and body fluids
- Hemoglobin variant analysis
- Molecular diagnostics
- Lipoprotein analysis
- Forensic and therapeutic drug screening
CE Instrument Components
Electroosmotic Flow (EOF)
Capillary Gel Electrophoresis
Micellar Electrokinetic Chromatography
Electroosmotic Flow (EOF)
We Offer CE & CE/MS System Leases to Fit Every Need
If you’re interested in a capillary electrophoresis instrument or system, but are seeking out an alternative solution to purchasing outright, we can help.
Our lease program can provide you with the electrophoresis equipment you need at an affordable rate, all while avoiding burdensome upfront costs of new machinery. In addition, every CE instrument lease comes with preventive maintenance and comprehensive repair coverage.
Request a lease estimate today and begin the quick and simple process of leasing your next piece of lab equipment.
Furthermore, if you’re involved in DNA sequencing, and plan on using your CE system in conjunction with your DNA sequencing efforts, but need to update or lease DNA sequencing equipment, let us know. We can help you source the equipment you need to fully outfit your laboratory and enable optimized workflows.
This off-balance sheet financing structure provides three options at the end of the term. The lessee has the option to return the equipment to the lessor, renew at a discounted rate, or purchase the instrument for the fair market value. Monthly payments are also 100% tax deductible which yields additional monetary savings.
If you recently bought equipment, Excedr can offer you cash for your device and convert your purchase into a long-term rental. This is called a sale-leaseback. If you’ve paid for equipment within the last ninety days, we can help you recoup your investment and allow you to make low monthly payments. This also frees up money in your budget rather than tying it down to a fixed asset.