- Stretching out payments over time removes the burdensome upfront cost of buying equipment
- Payments may be 100% tax deductible*, which yields you significant cash-savings
- It is cheaper to lease with Excedr than it is to buy outright
- Our worry-free repair coverage minimizes instrument downtime
- Excedr handles the admin work associated with equipment procurement and maintenance
- With the capital saved through our program, labs are better able to reinvest in their core business and operations (staffing, inventory, marketing/sales, etc.)
*Please consult your tax advisor to determine the full tax implications of leasing equipment.
All equipment brands/models are available
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Biolayer interferometry or BLI is an optical analytical technique that observes the associative and dissociative interaction of molecules. In chemistry, it is important to know substances affinity, thermodynamic properties, and their stoichiometry. Using white light, BLI looks at how molecules bind to or are disengaged from other molecules. BLI is also label-free, which is to say that BLI does not use any isotopes that would chemically bind to and label proteins. Useful in fragment screening, kinetic characterization, and real-time label-free chemical binding measurements BLI is an important tool in a wide variety of fields.
To measure biomolecular interactions BLI shines white light through a biosensor tip. This sensor tip has two surfaces inside of it: a reference layer and a layer of immobilized proteins on the sensor tip. As the proteins interact with the sample, some molecules will bind to them. The more molecules, or ligands, that bind to the protein, the more interference will occur with the light when it interacts with it. The resulting reflected light’s wavelength will then be shifted. This shifted wavelength is then compared to the wavelength from the reference material. The molecules that are bound or dissociating from the biosensor are the source of the interference pattern. Other factors such as unbound molecules, changes in flow rate, and the refractive index of the surrounding medium do not have the same effect. Because of this, the resulting data from BLI can give great insight into a substance’s kinetics, quantitation, affinity, as well as protein interactions.
Bio-Layer Interferometer Applications, Benefits, & Costs
Study of Kinetics
In chemistry, kinetics is the study of the rate that chemical processes occur. It is also called reaction kinetics. Real-time, label-free bio-layer interferometry is a useful tool used to observe these chemical processes. Specifically, binding rates and affinities lend themselves to this specific optical biosensing technique. BLI’s ability to quickly measure association rates, dissociation rates, and equilibrium dissociation constants without leaving behind label reagents makes it extremely valuable to the study of kinetics.
As populations grow and microbes evolve, fast and reliable vaccine research is becoming more and more important. BLI’s label-free and real-time testing capabilities make them fast and accurate tools for vaccine research. Areas of use for BLI within vaccine research are:
- Epitome design, characterization, and recognition studies
- Pathogen diversity and distribution
- Antibody affinity and development
- Host immune response characterization, diversity, and distribution studies
- Nucleic acid and molecular pathogen-host interaction studies
- Therapeutic and clinical studies
Analysis of Protein/Liposome Interactions
In drug screening and development, knowing the interaction of biologically relevant molecules and cell membranes is important. Artificial membrane systems, such as liposomes, are useful in determining these interactions due to their modularity. Their lipid composition, lipid ratio, and vesicle sizes can all be customized. BLI offers a number of important benefits to studying these interactions. The high throughput samples, being label-free, can be reused with no risk of clogging that is present in other similar techniques.
Analysis of Protein/Protein Interactions
For understanding biological processes, protein-protein interaction observations are important. BLI is an accurate label-free optical tool that is being used to look at these interactions. BLI is not affected by changes in the sample’s composition, unlike other methods. However, it is not as sensitive as those methods. This lack of change in the refractive index due to sample composition, alterations, its relative ease of use, and instrumentation flexibility make it a versatile tool for studying these type of interactions.
In 2005, ForteBio introduced bio-layer interferometry with its Octet instrument. Created to observe biomolecular interactions, the Octet systems allowed for real-time, label-free analysis of chemical affinity, kinetics, and concentrations. Since then BLI has become a robust optical analytical tool that is used in a wide variety of fields. Of particular note would be the advances made in the study of HIV-1. Since its discovery, our understanding of HIV has grown, however, a cure still remains elusive. Recently, with the help of BLI, scientists have begun to look deeper at how the HIV cells interact with specific envelopes in the body. If fully understood, these interactions could bring us one step closer to a cure that would help millions of people.
BLI is a robust tool that can help your lab succeed. The acquisition of such a vital piece of instrumentation should not force your lab to work at less than 100%. Here at Excedr, we want to help you get the most out of your equipment by offering an affordable leasing program that will leave you with more money to reinvest into your lab. Contact us today to learn more!
We Offer BLI Leases to Fit Every Need
This off-balance sheet financing structure provides three options at the end of the term. The lessee has the option to return the equipment to the lessor, renew at a discounted rate, or purchase the instrument for the fair market value. Monthly payments are also 100% tax deductible which yields additional monetary savings.
If you recently bought equipment, Excedr can offer you cash for your device and convert your purchase into a long-term rental. This is called a sale leaseback. If you’ve paid for equipment within the last ninety days, we can help you recoup your investment and allow you to make low monthly payments. This also frees up money in your budget rather than tying it down to a fixed asset.
BLI MACHINE MANUFACTURERS & MODELS ON THE MARKET
- Sartorius (formerly known as ForteBio): Octet RED96e, Octet HTX, Octet RED384, Octet QKe, Octet K2, BLItz System
- Gator Bio: Gator Bioanalysis System
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Effect on Credit & Operating Capital
Leasing/renting does not hinder your future borrowing ability and allows you to keep your business credit line open for expansions, staffing, and other operational expenses. Additionally, it strengthens the cash flow of your business and keeps cash reserves free for business development opportunities.
Unlike traditional financing and leasing companies, the Excedr program can accommodate refurbished/reconditioned equipment in addition to demo units. If you are looking for additional cost-savings, we recommend considering this option.
Speed of Approval
Excedr’s program allows you to respond quickly as your need for equipment and technology arises. You can be approved with minimal documentation and have the equipment you need in operation and generating revenue for your business quickly.